Bioactive Scaffolds for Skin Tissue Engineering Doped with Gold Nanoparticles Prepared from Waste Biomass

  • Julia RADWAN-PRAGŁOWSKA Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24 Street, 31-155 Cracow, Poland
  • Łukasz JANUS Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24 Street, 31-155 Cracow, Poland
  • Marek PIĄTKOWSKI Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24 Street, 31-155 Cracow, Poland
  • Aleksandra SIERAKOWSKA Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24 Street, 31-155 Cracow, Poland
  • Dariusz BOGDAŁ Cracow University of Technology, Faculty of Chemical Engineering and Technology, Warszawska 24 Street, 31-155 Cracow, Poland
DOI: https://doi.org/10.29227/IM-2020-01-61
Keywords: waste biomass, gold nanoparticles, chitosan, biomaterials, Green Chemistry

Abstract

Skin is the first barrier against pathogens and harmful external factors. Each damage of this tissue may cause microbial infection
and danger to internal organs. Burns which may be a result of the exposure to radiation, chemicals or high temperature leads to the
significant disruption of skin functions. The most promising method for this tissue recovery is regenerative medicine which requires
application of three-dimensional biocompatible scaffolds. The biomaterials enable skin cells proliferation and new tissue formation
under in vitro conditions. They can be prepared from synthetic and natural polymers and their combination. The application of additional components such as nanoparticles may enhance their mechanical properties and have a positive impact on fibroblasts divisions
and extra cellular formation. One of the most promising raw materials for scaffolds is chitosan -a chitin derivative. It may be obtained
from waste biomass such as crabs, shrimps and lobsters exoskeletons. Chitosan is non-toxic, biodegradable and have antibacterial
properties. The aim of the following study was to obtain novel chitosan derivatives doped with the gold nanoparticles using only natural components such as orange peels and fatty acid derivative. Proposed modification strategy resulted in the preparation of the novel,
biodegradable and biocompatible material with interesting properties. The products were analysed by UV-Vis and FT-IR methods.
The scaffolds were investigated over their susceptibility to enzymatic degradation. Finally, the biomaterials were verified over their
cyto-compability with human dermal fibroblasts. The results showed that the proposed synthesis pathway resulted in the obtained of
the chitosan biomaterials with high potential in medicine.

Published
2020-12-17
How to Cite
RADWAN-PRAGŁOWSKA, J., JANUS, Łukasz, PIĄTKOWSKI, M., SIERAKOWSKA, A., & BOGDAŁ, D. (2020). Bioactive Scaffolds for Skin Tissue Engineering Doped with Gold Nanoparticles Prepared from Waste Biomass. Test, 2(1), 169–173. https://doi.org/10.29227/IM-2020-01-61
Issue
Vol 2 No 1 (2020): Inżynieria Mineralna
Section
ARTICLES

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